By Pure Collagen.US
By Pure Collagen.US
On Skin Health
The best studies which supports the positive effects that the VERISOL® formula of collagen has on skin is from the recent human studies published in Skin Pharmacology and Physiology in 2012 and 2013. “Based upon these research results of the study, it can be concluded that the oral ingestion of specific collagen peptides led to a pronounced statistically significant reduction of skin wrinkle volume.”
The VERISOL® formula was also found to significantly increase skin elasticity making for a potentially younger skin appearance. The researcher further states that “the results presented are only valid for the specific collagen peptides composition (VERISOL®) used in this study.”
We, at Pure Collagen.US, have a high level of confidence in this product with Verisol® not only because of the excellent research methodology but also because they used human subjects in the research. Pure Collagen.Us has chosen to use the Verisol® product because we are vigorously committed to product quality.
The research studies which follow have not been conducted with our premier product VERISOL® but we feel that the studies with different animal species can add a broader conceptual support for the positive effects of collagen type 1 and type 3 with skin as the body ages.
Tanaka et.al., 2009 found that daily collagen peptide ingestion could “suppress UV-B induced decreases in skin hydration, and hyperplasia of the epidermis.” In summary collagen peptides are able to suppress UV-B induced skin and photo aging.
Oral ingestion of collagen can increase the production of collagen produced by the body. Aoki M., 2012 also found that there was an increase in the amount of collagen in the skin as a result of oral intake of lhydrooxyproline.
Further Matsuda N. et.al., 2006, found that “oral collagen ingestion in pigs increased the amount of the extracellular matrix in the dermis. This further suggests that oral ingestion of collagen peptide induces increased fibroblast density and enhances the formation of collagen fibers in the dermis”.
Zagreb, VA. et.al.,2001, studied the effects of oral intake of collagen hydrolysalate on the increase of collagen in the skin. He found that daily doses of collagen hydrolysalate increased the “age-related changes of the extracellular matrix by stimulating anabolic processes in skin tissue”.
Liam, J. et.al., 2010, found that marine derived collagen hydrolysate had “protective effects on chronological skin aging due to the influence of collagen matrix homeostasis.”
Collagen hydrolysate ingestion elasticity has been found to improve skin elasticity with induced UV-B radiation in hairless mice. In summary research has suggested the following effects of oral ingestion of hydrolyzed types 1 and 3 collagen:
On Joints, Cartilage and Bones
It is well known that, as we age, there is a significant loss in collagen production. This significant loss of collagen, in especially the high compression and impact joints, causes the fibrous mesh on the ends of the bones to decrease whereby decreasing the amount of cushion at the site of the joints. Then as movement occurs, there is likely to be an increase in joint pain and decreases in mobility. Research has revealed that there are two methods of increasing the amounts of type 2 collagen in the higher impact joint areas.
The first method of increasing the amount of collagen type 2 in the joint areas is by the oral ingestion of hydrolyzed type 2 collagen directly in daily doses. The second is through the oral ingestion of a specially manufactured formula of type 1 and type 3 collagen called Fortagel. Fortagel has been shown through many research experiments, for many years, to increase the body’s own production of type 2 collagen.
Both methods have repeatedly shown a significant decrease in joint pain and an increase of joint comfort as a result of the oral ingestion of hydrolyzed collagen.
It has been suggested that type 2 collagen could have a facilitatory effect on the health of joints and bones.
Moskowitz, 2000, states that collagen hydrolysate is of interest as a therapeutic agent of potential utility in the treatment of osteo arthritis and osteoporosis.
O’Hara H. et al, 2010, found that the oral administration of pro-hypa collagen hydrolysate-derived peptide “increases the amount of proleoglycins in the epiphysis and reduced themorphological changes associated with osteoarthritic cartilage destruction of the knee. The results suggest that collagen hydrolysates have therapeutic potential for treatment of osteoarthritis.”
Regarding the potential facilitatory effects of type 2 collagen on rheumatoid arthritis, Choy EH, et al, 2001, found results showing that in a randomized double-blind study oral ingestion of. 5 milligrams per day of type II collagen produced positive effects on rheumatoid arthritis. This was without any side effects.
Watanabe-Kamlyama M. et al., 2010 studied the absorption and effectiveness of orally administered low molecular-weight (LMW) collagen hydrolysate (CH) in rats. They stated that “our findings show that LMW-CH exerts a beneficial effect on osteoporosis by increasing the organic substance content of bones.
Takeda, S. et al., 2013, study the effects of hydrolyzed collagen (HC) intake on bone mass of growing rats in running exercises. They found that just “moderate intake where the diet contains 20 percent protein of which 30 percent is HC increased bone mass during growth period and further promoted the effects of running exercises.”
Moskowitz, 2000, writes in a seminar on rheumatoidartheritis “hydrolyzed gelatin products have long been used in pharmaceuticals and foods. These products are generally recognized as safe food products by regulatory agencies. Pharmaceutical grade collagen hydrosylate (PCH) is obtained by hydrolysis of pharmaceutical gelatin. Clinical studies suggest that the ingestion of 10 grams PCH daily reduces pain in patients with osteoarthritis of the knee or hip. Blood concentration of hydroxyproline is increased.” The greater the pre-treatment pain symptoms the greater was the result.
Benito Ruiz, et.al., 2009, with a double-blind controlled multi-center trial of 250 subjects with primary osteoarthritis of the knee, when given 10 grams of collagen hydrolysate they found significant improvement in knee joint comfort as assesed by a visual analogue scale to assess pain and on the WOMAC pain subscale. “Subjects with the greatest joint destruction with least intake of meat protein in their habitual diets benefited most”.
Benito Ruiz, et. al., 2009, summarizes this randomized double-blind controlled multi-center 250 human subject experiment by stating that “current options to promote joint comfort are limited to medicines that can reduce pain but can also have adverse side effects. Collagen, a major component of joint cartilage, is found in the diet, partially in meat. Its hydrolyzed form, collagen hydrolysate (CH) is well absorbed. CH may stimulate the joint matrix cells to synthesize collagen, so helping to maintain the surface of a joint and potentially to aid joint comfort”.
Clark KL et al, 2008, in a 24-week experiment with athletes treated with collagen hydrolysate found significant improvement in joint pain.
Oesser, S. et. al., 1999, determined that gelatin hydrolysate was absorbed through the small intestines and was 95 percent absorbed within 12 hours after ingestion. They found that gelatin hydrolysate was significantly absorbed by cartilage and skin areas.